Serpooshan
for tissue manufacturing & analysis
Lab
video courtesy of Advanced Solutions
About Us
The Serpooshan Team uses a multidisciplinary approach to design and develop micro/nano-scale tissue engineering technologies with the ultimate goal of generating functional tissues and organs. Current projects in my lab include:
1) Bioengineering iPSC-based, functional cardiovascular tissue models, via 3D bioprinting technologies, as in vitro platforms to study human heart development and diseases;
2) Design and manufacturing novel patient-specific cardiac patch systems to regenerate damaged myocardium following ischemic heart injury;
3) 3D bioprinting of functional in vitro models of cortical organoids to study human brain development; and
4) Engineering highly tunable bioprinted models to study pediatric tumor growth, aggression, and response to therapies.
OUR LINES OF RESEARCH
Using state-of-the-art 3D bioprinting, perfusion bioreactor, and induced pluripotent stem cell technologies to engineer in vitro models of human heart development and diseases. Studying various cellular and environmental factors underlying congenital heart defects and their therapies.
Synthesis, characterization, and application of various nano/micro-scale biomaterials for diverse biomedical applications in vitro and in vivo. Examples include: magnetic nanoparticles for antibacterial and imaging applications, conductive nanorods to enhance cardiac tissue function, and nanostructured scaffolds.
Meet The Team
Vahid Serpooshan, PhD
Principal Investigator
Vahid Serpooshan did his BSc and MSc in Materials Science and Engineering at Sharif University (Tehran, Iran, 1998-2003) and his PhD in biomaterials and tissue engineering at McGill University (Montreal, Canada, 2007-2011). His PhD thesis research focused on the design and optimization of scaffolding biomaterials for bone tissue engineering applications. Following his PhD, Dr. Serpooshan worked for 7 years at Stanford University School of Medicine as Postdoctoral Fellow (Pediatric Cardiology) and Instructor (Stanford Cardiovascular Institute). At Stanford, Dr. Serpooshan's training and research were mainly centered on developing a new generation of engineered cardiac patch device to repair damaged heart tissue following myocardial infarction (heart attack). The engineered patch was successfully tested in mouse and pig models and is now in preparation for clinical trials. He also worked on enabling technologies for human-machine hybrid cardiac tissue, using 3D bioprinting to assemble complex arrays of interfaces between synthetic and biological materials. In 2018, Dr. Vahid Serpooshan joined Emory University and Georgia Institute of Tech as Assistant Professor of Biomedical Engineering and Pediatrics, where his multidisciplinary team is now working on a variety of 3D bioprinting-based tissue engineering and disease modeling projects.
Assistant Professor of Biomedical Engineering
and Pediatrics
Georgia Institute of Technology
Emory University School of Medicine
404.712.9717
Holly Bauser-Heaton is an interventional pediatric cardiologist and physician scientist at Sibley Heart Center at Children’s Healthcare of Altanta. She completed her MD, PhD in 2009 at Indiana University. Dr. Bauser-Heaton focused on signaling mechanisms of nitric oxide in hypoxic conditions and continues to investigate the role of NO in endothelial function. As a clinician, she completed her training at Stanford University and joined faculty of Sibley Heart Center in 2016. Pulmonary artery disease and its management is the focus for Dr. Heaton both in the clinical arena and the lab. She is interested in developing new procedures via transcatheter (in the cardiac catheterization laboratory) technique for individuals with pulmonary artery disease. Additionally, she has interest in utilizing 3D bioprinting to create pulmonary artery constructs that have the ability to keep up with a patient’s somatic growth. She is very excited to join forces with the Serpooshan lab.
Holly Bauser-Heaton, MD PhD
Assistant Professor
Pediatric Cardiologist
Sibley Heart Center, Pediatric Cardiology
Emory University School of Medicine
Sarah Rezapour, MD
Sarah Rezapour earned her MD degree from Tehran University of Medical Sciences (Tehran, Iran) in 2015. Following the completion of her degree, she embarked on a three-year practice in the field of medicine, gaining invaluable experience in patient care and medical practice. With a passion for delving deeper into the unmet needs in clinical settings, Dr. Rezapour transitioned to the research arena, joining the Tehran Research Institute of Gastrointestinal and Liver Diseases. Her project was directed toward unraveling the complex pathways involved in non-alcoholic steatohepatitis (NASH) progression and developing novel approaches for diagnosis and treatment. Sarah joined the Serpooshan lab in May 2023 as a postdoctoral research fellow. In her current role, she mainly focuses on Fontan-associated liver disease (FALD). Her project centers on biofabrication and in vitro culture strategies for constructing a vascular 3D model of the healthy human liver (hepatic sinusoid) vs. FALD tissue models.
Postdoctoral Fellow
Departments of Biomedical Engineering and Pediatrics
Emory University School of Medicine
Georgia Institute of Technology
Mehdi Salar Amoli received his BSc from Amirkabir University of Technology (Tehran Polytechnique, Iran), studying biomaterials and tissue engineering, and performing research on osteochondral tissue engineering. Next, he moved to London, where he continued studies in the field of biomaterials and tissue engineering at Imperial College London (ICL), conducting research at Dr. Molly Stevens group on nanoneedle based gene delivery techniques. Following his training at ICL, Mehdi moved to Belgium, where he received his PhD from KU Leuven. His doctoral research focused on development of bioinks for 3D bioprinting strategies aimed at regeneration of the dentoalveolar tissues. During his PhD, he focused on development of a range of stimuli-responsive biomaterials for bioprinting, sustained release delivery systems for incorporation of drugs and growth factors, as well as physical, mechanical and biological characterization of tissue engineered constructs. In 2023, Mehdi joined Serpooshan lab, where his main research focus is to develop in vitro disease models using bioprinting.
Mehdi Salar Amoli, PhD
Postdoctoral Fellow
Departments of Biomedical Engineering and Pediatrics
Emory University School of Medicine
Georgia Institute of Technology
Jemma Hwang, BS, BA
Lead Research Specialist
Departments of Biomedical Engineering and Pediatrics
Emory University School of Medicine
Georgia Institute of Technology
Jemma Hwang received her BS in Bioengineering and BA in German Studies (2019) from the University of Georgia where they began their research endeavors in epigenetics to identify mutants in N. crassa that are defective in facultative heterochromatin. In 2017, they obtained an internship at the Perfusion Systems Lab of Merck KGaA in Darmstadt, Germany to improve existing downstream processes of protein production in industry settings. In the Summer of 2018, they participated in the Summer Undergraduate Research Program (SURP) with the Sackler Institute at New York University, studying the electrophysiology and molecular biology of ATP-sensitive potassium channels. After completing their Bachelor’s, they accepted a position at the Duke Human Vaccine Institute to contribute to the ongoing development of vaccines against HIV-1. In December 2022, Jemma joined the Serpooshan-Bauser-Heaton Labs as the Lead Research Specialist. They are using their management experience to support active projects within the lab, while also leading the synthesis of gelatin methacrylate (GelMA).
Yamini Singh, B.Tech, Sc.M.
Research Specialist
Departments of Biomedical Engineering and Pediatrics
Emory University School of Medicine
Georgia Institute of Technology
Yamini Singh received her B.Tech. in Biomedical Engineering from Manipal Institute of Technology, India (2021) and her Sc.M. in Biomedical Engineering from Brown University (2023). While at Brown, she worked in the laboratories of Dr. Kareen Coulombe and Dr. Anita Shukla for her Master’s thesis which was focused on the optimization of hydrogels for core-shell 3D bioprinting of patterned vessels for engineered cardiac tissues. Yamini joined the Serpooshan Lab in August 2023 as a Research Specialist, contributing both to the lab managerial workflow as well as working on several research projects on the 3D bioprinted in vitro models of diseases and therapies.
Graduate Students
Carmen J. Gil
PhD Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Linqi Jin
PhD Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Lama Rita El Shammas
MS Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Boeun Hwang
PhD Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Zahra Alghoul
MS Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Melissa Cadena
PhD Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Maher Saadeh
PhD Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Vani Sridhar
MS Student
Wallace H. Coulter Department of Biomedical Engineering
Emory University and
Georgia Institute of Technology
Undergraduate Students
Roshni Nandwani
Undergraduate Researcher
Emory University
Yuxiao Wu
Undergraduate Researcher
Georgia Institute of Technology
Amritaa Basu
Undergraduate Researcher
Georgia Institute of Technology
Wyatt DeBord
Undergraduate Researcher
Georgia Institute of Technology
Pranitha Kaza
Undergraduate Researcher
Georgia Institute of Technology
Sarah Fineman
Undergraduate Researcher
Georgia Institute of Technology
Lab Alumni
Martin L. Tomov, PhD
Now: Associate Director, Innovation Cores @ Emory School of Medicine
Liqun Ning, PhD
Postdoctoral Fellow
Now: Assistant Professor @ Cleveland State University
Zinah Ghazi
Research Specialist
Now: Keller Williams Realty
Stefano Zanella
Andrea Theus
Mostafa Abdalla
BME MS Student
Now: Medtronic
Research Specialist
Now: Assoc Engineer at BD
Research Specialist
Now: USPTO
Anjum Alam
Undergraduate Researcher
Georgia Institute of Technology
Katherine Pham Do
Research Specialist
Now: Medical School
Rosemary Tran
Undergraduate Researcher
Emory University
Faiza Syed
Undergraduate Researcher
Georgia Institute of Technology
Jayce Schwartz
Undergraduate Researcher
Georgia Institute of Technology
Caroline Harpole
Undergraduate Researcher
Georgia Institute of Technology
Alex Cetnar
Linqi Jin
Gabriella Kabboul
Joy E. Nish
BME MS Student
Now: R&D Eng II @ Medtronic
BME MS Program
Now: BME PhD Student @ Serpooshan Lab
Undergraduate Researcher
Now: PhD Student @ Levit Lab
Undergraduate Researcher
Georgia Institute of Technology
Riya Mehta
Davis White
Corinna Shimalla
Victor Putaturo
Undergraduate Researcher
Emory University
Undergraduate Researcher
Georgia Institute of Technology
Undergraduate Researcher
Georgia Institute of Technology
Undergraduate Researcher
Georgia Institute of Technology
Federico Prokopczuk
Hannah Komanapalli
SURE Program 2018
California State University, Northridge
SURE Program 2018
Purdue University
Rommi Kashlan
Rebecca R. Xu
High School Intern
Now @: BME Undergrad at Georgia Tech
Undergraduate Researcher
Georgia Institute of Technology
Huyun Chen
Kevin M. McCoy
Undergraduate Researcher
Georgia Institute of Technology
Undergraduate Researcher
Georgia Institute of Technology
Bryanna J. Lima
Undergraduate Researcher
Georgia Institute of Technology
Rithvik Sarasani
Undergraduate Researcher
Georgia Institute of Technology
Alpravinta Alagesan
Agastya Vaidya
Allison Wombwell
Undergraduate Researcher
Georgia Institute of Technology
Undergraduate Researcher
Emory University
Undergraduate Researcher
Georgia Institute of Technology
RECENT PUBLICATIONS
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L. Ning, J. Shim, M.L. Tomov, R. Liu, R. Mehta, A. Mingee, B. Hwang, L. Jin, A. Mantalaris, C. Xu, M. Mahmoudi, K.C. Goldsmith, V. Serpooshan. A 3D bioprinted in vitro model of neuroblastoma recapitulates dynamic tumor-endothelial cell interactions contributing to solid tumor aggressive behavior. Advanced Science, 9 (23), 2200244, 2022.
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J.W. Buikema, …, V. Serpooshan, S. Jovinge, B.K. Fleischmann, P.A. Doevendans, J. van der Velden, K.C. Garcia, J.C. Wu, J. PG Sluijter, and S.M. Wu. Wnt activation and reduced cell-cell contact synergistically induce massive expansion of functional human iPSC-derived cardiomyocytes. Cell Stem Cell, 27, 50-63, 2020.
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M. Mahmoudi, M. Yu, V. Serpooshan, J.C. Wu, R. Langer, R.T. Lee, J.M. Karp, and O.C. Farokhzad. Multiscale technologies for treatment of ischemic cardiomyopathy. Nature Nanotechnology, 12, 845-55, 2017.
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K. Wei+, V. Serpooshan+ (Co-First Author), …, M.D. Schneider, M.J.B. van den Hoff, M.J. Butte, P.C. Yang, K. Walsh, B. Zhou, D. Bernstein, M. Mercola, and P. Ruiz-Lozano. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature, 525, 479-85, 2015.
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S. Chen, M.L. Tomov, L. Ning, C.J. Gil, B. Hwang, H.D. Bauser‐Heaton, H. Chen, and V. Serpooshan. Extrusion‐based 3D bioprinting of adhesive tissue engineering scaffolds using hybrid functionalized hydrogel bioinks. Advanced Biology, 7 (7), 2300124, 2023.
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S. Neelakantan, M. Kumar, E.A. Mendiola, H. Phelan, V. Serpooshan, S. Sadayappan, R. Avazmohammadi. Multiscale characterization of left ventricle active behavior in the mouse. Acta Biomaterialia, 162, 240-253, 2023.
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M.J. Hajipour, R. Safavi‐Sohi, S. Sharifi, N. Mahmoud, A.A. Ashkarran, E. Voke, V. Serpooshan, M. Ramezankhani, A.S. Milani, M.P. Landry, and M. Mahmoudi. An overview of nanoparticle protein corona literature. Small, 19 (36), 2301838, 2023.
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L. Ning and V. Serpooshan. Giant salamander-derived hydrogel granules with superior bioadhesive properties. Matter, 5 (9), 2581-2584, 2022.
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A.S. Theus, L. Ning, G. Kabboul, B. Hwang, M.L. Tomov, C.N. LaRock, H.D. Bauser-Heaton, M. Mahmoudi, V. Serpooshan. 3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties. iScience, 25 (9), 104947, 2022.
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L. Ning, M.L. Tomov, S. Zanella, B. Zambrano, R. Avazmohammadi, M. Mahmoudi, H.D. Bauser-Heaton, and V. Serpooshan. Magnetic nanoparticle-mediated targeting of endothelium to address restenosis in a bioprinted in vitro model of pulmonary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 42, A550, 2022.
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S. Sharifi, A. Ata Saei, H. Gharibi, N.N. Mahmoud, S. Harkins, N. Dararatana, E.M. Lisabeth, V. Serpooshan, Á. Végvári, A. Moore, M. Mahmoudi. Mass spectrometry, structural analysis, and anti-inflammatory properties of photo-cross-linked human albumin hydrogels. ACS Applied Bio Materials, 5 (6), 2643-2663, 2022.
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J.Q. Ho, M.R. Sepand, B. Bigdelou, T. Shekarian, R. Esfandyarpour, P. Chauhan, V. Serpooshan, L.K. Beura, G. Hutter, S. Zanganeh. The immune response to COVID‐19: Does sex matter? Immunology, 166 (4), 429-443, 2022.
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C.J. Gil, L. Li, B. Hwang, M. Cadena, A.S. Theus, T.A. Finamore, H. Bauser-Heaton, M. Mahmoudi, R.K. Roeder, V. Serpooshan. Tissue engineered drug delivery vehicles: Methods to monitor and regulate the release behavior. Journal of Controlled Release, 349, 143-155, 2022.
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L. Li, C.J. Gil, T.A. Finamore, C.J. Evans, M.L. Tomov, L. Ning, A.S. Theus, G. Kabboul, V. Serpooshan, R.K. Roeder. Methacrylate-modified gold nanoparticles enable noninvasive monitoring of photocrosslinked hydrogel scaffolds. Advanced NanoBiomed Research, 2 (7), 2200022, 2022.
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M.L. Tomov, L. Perez, L. Ning, H. Chen, ..., J. Zhang, R. Avazmohammadi, A. Mantalaris, B.D. Lindsey, D. Frakes, L.P. Dasi, V. Serpooshan, and H. Bauser-Heaton. A 3D Bioprinted In Vitro Model of Pulmonary Artery Atresia to Evaluate Endothelial Cell Response to Microenvironment. Advanced Healthcare Materials, 10 (20), 2100968, 2021.
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M. Mahmoudi, V. Serpooshan, P.C. Yang, and M. Heydarpour. The effect of cell sex on magnetic nanoparticle uptake of human induced pluripotent stem cell-derived cardiomyocytes. Circulation Research, 129, AP392-AP392, 2021.
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C.J. Gil, C. Evans, L. Li, M. Vargas, G. Kabboul, T. Fulton, R. Veneziano, N. Willet, H. Bauser-Heaton, R.K. Roeder, and V. Serpooshan. A precision medicine approach for non-invasive, longitudinal, and quantitative monitoring of cardiac tissue-engineered scaffolds. Circulation Research, 129, AMP207-AMP207, 2021.
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M. Mahmoudi, P.C. Yang, , P. Abadi, and M. Heydarpour. The effect of cell sex on cardiogenic differentiation of human induced pluripotent stem cells and their maturation processes. Circulation Research, 129, A109-A109, 2021.
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S. Chen, M.L. Tomov, L. Ning, C.J. Gil, B. Hwang, H. Bauser-Heaton, and V. Serpooshan. Three-dimensional bioprinting of adhesive cardiac patch systems. Circulation Research, 129, AP403-AP403, 2021.
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M. Zhao, Y. Nakada, Y. Wei, W. Bian, Y. Chu, A.V. Borovjagin, M. Xie, W. Zhu, T. Nguyen, Y. Zhou, V. Serpooshan, G.P. Walcott, and J. Zhang. Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation, 144 (3), 210-228, 2021.
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M.J. Hajipour, H. Aghaverdi, V. Serpooshan, H. Vali, S. Sheibani, and M. Mahmoudi. Sex as an important factor in nanomedicine. Nature Communications, 12, 2984-3010, 2021.
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L. Ning, N. Zhu, A. Smith, A. Rajaram, H. Hou, S. Srinivasan, F. Mohabatpour, L. He, A. Mclnnes, V. Serpooshan, P. Papagerakis, and X. Chen. Noninvasive Three-Dimensional In Situ and In Vivo Characterization of Bioprinted Hydrogel Scaffolds Using the X-ray Propagation-Based Imaging Technique. ACS Applied Materials & Interfaces, 13, 25611, 2021.
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O. Chirikian, W.R. Goodyer, E. Dzilic, V. Serpooshan, J.W. Buikema, W. McKeithan, H. Wu, G. Li, S. Lee, M. Merk, F. Galdos, A. Beck, A. JS Ribeiro, S. Paige, M. Mercola, J.C. Wu, B.L. Pruitt, and S.M. Wu. CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes. Scientific Reports, 11, 1, 2021.
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M. Shokouhimehr, A.S. Theus, A. Kamalakar, L. Ning, C. Cao, M.L. Tomov, J.M. Kaiser, S. Goudy, N.J. Willett, H.W. Jang, C.N. LaRock, P. Hanna, A. Lechtig, M. Yousef, J. Da Silva Martins, A. Nazarian, M.B. Harris, M. Mahmoudi, V. Serpooshan. 3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration. Polymers, 13, 1099, 2021 (Editor's Choice).
CONTACT US
Emory (primary) lab address:
1750 Haygood Dr.
Room S435 (4th floor)
Emory University School of Medicine
Atlanta, GA 30322
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Georgia Tech address:
313 Ferst Dr NW
Georgia Inst. of Tech.
Atlanta, GA 30332
vahid.serpooshan@bme.gatech.edu
Office: 404-712-9717
